Pregnancy advances your 'biological' age — but giving birth turns it back – Nature.com

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Aches and pains aren’t all that pregnancy shares with ageing. Brewing a baby leads to changes in the distribution of certain chemical markers on a pregnant person’s DNA — changes similar to those that are a hallmark of getting older. But new research shows that, several months after a person gives birth, the chemical patterns revert to an earlier state1. The results strengthen previous work in mice and preliminary results in humans2.

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Nature 628, 18-19 (2024)
doi: https://doi.org/10.1038/d41586-024-00843-w
Clarification 25 March 2024: This article has been updated to provide a clearer account of Dena Dubal’s thinking about methylation.
Pham, H. et al. Cell Metab. https://doi.org/10.1016/j.cmet.2024.02.016 (2024).
Article  Google Scholar 
Poganik, J. R. et al. Cell Metab. 35, 807–820.e5 (2023).
Article  PubMed  Google Scholar 
Samani, N. J. & van der Harst, P. Heart 94, 537–539 (2008).
Article  Google Scholar 
Wu, J. W. et al. Sci. Rep. 11, 15929 (2021).
Article  PubMed  Google Scholar 
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How the Great Depression shaped people’s DNA
Pregnancy and COVID: what the data say
‘Inflammation clock’ can reveal body’s biological age
First hint that body’s ‘biological age’ can be reversed
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