Pregnancy advances your 'biological' age — but giving birth turns it back –

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Aches and pains aren’t all that pregnancy shares with ageing. Brewing a baby leads to changes in the distribution of certain chemical markers on a pregnant person’s DNA — changes similar to those that are a hallmark of getting older. But new research shows that, several months after a person gives birth, the chemical patterns revert to an earlier state1. The results strengthen previous work in mice and preliminary results in humans2.

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Nature 628, 18-19 (2024)
Clarification 25 March 2024: This article has been updated to provide a clearer account of Dena Dubal’s thinking about methylation.
Pham, H. et al. Cell Metab. (2024).
Article  Google Scholar 
Poganik, J. R. et al. Cell Metab. 35, 807–820.e5 (2023).
Article  PubMed  Google Scholar 
Samani, N. J. & van der Harst, P. Heart 94, 537–539 (2008).
Article  Google Scholar 
Wu, J. W. et al. Sci. Rep. 11, 15929 (2021).
Article  PubMed  Google Scholar 
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How the Great Depression shaped people’s DNA
Pregnancy and COVID: what the data say
‘Inflammation clock’ can reveal body’s biological age
First hint that body’s ‘biological age’ can be reversed
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